Victoza Effective in Youth With Type 2 Diabetes: Study


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The injectable diabetes medicine Victoza (liraglutide), a member of the class of medicines known as GLP-1 agonists[1], is effective in children and adolescents ages 10–17 with type 2 diabetes[2], according to a new study in The New England Journal of Medicine[3].

In the phase ELLIPSE study, Victoza combined with metformin[4] significantly reduced A1C[5] levels (a measure of glucose control over the previous 2–3 months) compared to placebo (inactive treatment) with metformin: Victoza reduced A1C by 0.64% and 0.5%, respectively, at 26 and 52 weeks, compared to placebo, which caused a rise of 0.42% and 0.8%.

According to lead researcher William Tamborlane, MD, “These data represent a potential new treatment option for lowering blood sugar in children and adolescents with type 2 diabetes.”

Victoza is currently approved for use along with diet[6] and exercise[7] in adults with type 2 diabetes. Manufacturer Novo Nordisk has submitted the results of the trial to the U.S. Food and Drug Administration (FDA) to support a labeling extension.

Want to learn more about type 2 diabetes in children? Read “Children and Type 2 Diabetes: What’s New?”[8] and “Recognizing Type 2 Diabetes in Children and Adolescents.”[9]

Endnotes:
  1. GLP-1 agonists: https://www.diabetesselfmanagement.com/blog/non-insulin-injectable-diabetes-medications/
  2. type 2 diabetes: https://www.diabetesselfmanagement.com/diabetes-resources/definitions/type-2-diabetes/
  3. The New England Journal of Medicine: https://www.nejm.org/doi/full/10.1056/NEJMoa1903822
  4. metformin: https://www.diabetesselfmanagement.com/managing-diabetes/treatment-approaches/metformin-2/
  5. A1C: https://www.diabetesselfmanagement.com/managing-diabetes/blood-glucose-management/h-b-a-1-c/
  6. diet: https://www.diabetesselfmanagement.com/nutrition-exercise/meal-planning/
  7. exercise: https://www.diabetesselfmanagement.com/nutrition-exercise/exercise/
  8. “Children and Type 2 Diabetes: What’s New?”: https://www.diabetesselfmanagement.com/about-diabetes/kids-diabetes/children-type-2-diabetes-whats-new/
  9. “Recognizing Type 2 Diabetes in Children and Adolescents.”: https://www.diabetesselfmanagement.com/about-diabetes/kids-diabetes/recognizing-type-2-diabetes-in-children-and-adolescents/

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