Type 2 Study Looking for Volunteers

If you’ve been diagnosed with Type 2 diabetes within the past five years, then you may be eligible to help researchers test treatments in a study sponsored by the National Institutes of Health (NIH).


Current guidelines typically recommend the oral drug metformin as a first-line treatment, along with a healthful diet and exercise. If metformin isn’t enough to control a person’s blood glucose levels, doctors will sometimes add another medicine, but no long-term studies have been conducted to determine which combination of drugs works best and has the fewest side effects.

To address this, NIH has launched a long-term clinical trial known as the GRADE study, in which investigators will examine the pros and cons of using common diabetes medicines along with metformin.

The study aims to enroll about 5,000 volunteers in 37 locations across the United States. All participants will take metformin, along with a second medicine randomly assigned from among four classes of drugs approved for use with metformin by the FDA.

Volunteers will receive their medicine for free during the study. Other health-care must come from their usual providers.

For more information about the study, including locations of participating centers, click here.

This blog entry was written by Web Editor Diane Fennell.

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  • Katie Munro

    Type 2. I would volunteer. But I live in scotland

  • Anjali

    I’m Type 2 and would like to volunteer … however,
    What if I’m not taking metformin?
    And I’m taking glynase instead?
    Metformin has affected my digestive system…
    so it doesn’t suit me?
    what are the options?

  • Marleneemm

    I’ve been on Metformin for about a little over a
    year, I take 1 tablet in the morning/night..
    I’d love to voulenteer but I don’t have any way
    to get to the place where the clinical trial is
    held as I don’t drive.

  • Amber

    I currently take Metformin, along with Bydureon and it works very well for me. Not sure if this study is for me, but if you want to look at numbers from what I’ve already been treated with, you are more than welcome. Previously, I was taking Metformin and Byetta, that also worked well…my doctor finds that bydureon has benefited me most over all with an AC1 of 5.1.

  • Amanda

    I live in the Cleveland area and am speaking with the VA hospital, however, I wonder if I won’t be eligible since I’m not a veteran.

  • Nancy

    I would like to volunteer but I am on long acting insulin. Used metformin for many years and continue with these two medications and able to keep HA1c at 6.1 most of the time.

  • Bea

    I live in the Philadelphia (PA) area and have been on Metformin. How can I get in the trial?

  • james weiss

    I take metformin plus bydureon for my diabetes and would like to volunteer for the study. I am 76 years old and live in Oregon

  • Jody Williams

    I am called a type 2 diabetic and have had it for about 24 years. I can’t get insurance because I have it, but I need to be able to take care of it and control it, so I would volunteer for this study. In the past metformin like many patients gives you severe gas/bloating, so maybe a different combination of drugs would improve on this?? Someone can contact me and discuss if I would be a good candidate for the study.


  • Donna

    I have been taking Metaforim along with Glimpride for several years, and the Dr. has just added Acthos to the three… no results have come as yet, as I have just within the last month been on the 3 meds for Diabetes. I was diagnosed over 10 years ago… my daily tests are between 78 a low, to 154 a high…. I am 84 years old, and have always been fairly active, and am somewhat overweight, probably about 15 to 20 pounds more that I would like to be, but I can’t seem to lose any but stay at the same weight. The Dr. has wanted to put me on injections of insulin, but I am fighting that. Any suggestions. I do watch my diet, and keep active. In pretty good health otherwise. have some arthritus in my back.

  • Robert Barwig

    I’ was diagnosed with type 2 about 10 years ago. Would you consider me?

  • Brenda Marie

    I would love to be a volunteer. I have type2 diabetes and am currently unemployed, so any help with my medication would be helpful, (especially since I do not have any health insurance).

    I believe stress of not know if I will loose my apartment due to lack of work is reaking havoc with my glucose numbers! My A1C has risen as well, 7.1 now. Carbs and stress are a killer. I am a foodie, and am a comfort eater so there have been extra carbs these days, (I know better).

  • Micghael A. Fisher

    I live 350 miles from San Diego. I would love to be apart of Metformin Type 2 study, but the drive would kill this 72 year old. Thanks; But no thanks.

  • Irene James

    I’ve been on Metformin for about 6 years…Doctor recently increased my dosage to 1000mg twice a day instead of 500mg. If I meet the requirements would like to help.

    Thank you!

  • Diane Fennell

    Hi everyone,

    Thanks for all your comments so far! Just a quick note to mention that anyone who has any questions about this trial or who is interested in volunteering should contact the clinical site nearest them. An interactive map of the participating sites, which includes links to the sites’ homepages, can be found here (zoom out to view sites across the country): https://grade.bsc.gwu.edu/web/grade/clinical-centers

    Diane Fennell
    Web Editor

  • Dorothy

    I took 1 10mg tablet of Metformin before bed. I awoke at 4AM with NO feeling in my arms or legs. I later met someone who worked for the company that produced the drug, and he told me that less than 1% of the test subjects had that reaction, so it was not necessary to include that information on the package insert. This incident happened when Glucophage first came out in the late 1990’s I was diagnosed with type II in 1987. I am now on 3 kinds of insulin, and NO Diabetes meds. They ALL caused problems for me, eg: weight gain, swelling, fatigue, joint pain, dizziness,etc.
    Don’t be afraid of the needles, because the pen needles are so comfortable.

  • Theresa

    I was diagnosed as type 2 diabetic in 2008 and have been taking Metformin and Januvia. For a short period of time I was taking Janumet which made me very tired. When the doctor diagnosed my condition I was overweight and have lost 35 lbs., my A1C was 7.0 and is now 6.0. I weight-train 2 times a week. I would like to partipate, but I am a full-time employee an nd I live in Maryland.

  • Ferne

    I take metformin and glimepiride. Metformin is good for diabetes but the gastrointestinal side affects are hell.

  • Don Carson

    I have type 2.I have use metformin for 5 years I have lost 100 lbs and my AIC levels have dropped to 5.5. I take it once in the morning and once at dinner.I can not excersize do OA I have no cartaledge left any where.I was diagnosed 6 years ago.
    Posted August 14 2013 by Don

  • Robert

    back in 2001 while at work suffered a heart attack then was told that I was Type 2 diabetic, controlled B.S. by diet and exercise but as I age my doc has put me on Metformin to control blood sugar. If I can be of any help in this survey, don’t hesitate to contact me.

  • Brian Kelly

    I was diagnosed as type 2 diabetic in 2004 and have been taking 2 to 3 tabs a day of Metformin. When the doctor diagnosed my condition I was 40 pounds overweight and have lost 45 pounds.(currently 6’1 and 200 pounds) in the last 3 years, my A1C was 6.6 and is now 6.0. I weight-train 3 times a week with a multi-system Marcy gym. I would like to consider participating should I be accepted as a volunteer.

  • Angel

    I would love to find a trial that I would be able to participate in, but they always want people with high A1C’s. I always run 5.9 or less. Let me know when you need someone like me!

  • barbara

    I have been on metformin and also am on Januvia. I would be interested in the study

  • Deb

    I would love to but I live in Wisconsin and nothing close. To bad as I also run two Diabetes support groups in the area.

  • H. Brown

    I have been a type 2 diabetic since fall of 1983. I started Mediformin in 95. In abouot 2003 I started taking Glipizde. Two years later I started on insulin. I take 1000 mg of metformin twice a day along with glipizide. I take 7 nits of insulin at bedtime. This summer I had to have lazer surgery on my one eye.

  • Kathleen

    If I have been on Metformin for over 10 years am I ineligible? I also take Glipizide and Januvia. I take the Metformin 1000 twice a day. I started taking Glipizide 5mg twice a day and have seen some lowering on my blood glucose. I’m not the best about my diet and exercise, but I really don’t want to have to use insulin!! I live near San Francisco.

  • Don Mazza

    Live in Albany,GA area, and would like to help out in the study group. Have been type 2 for about 6 years how.

  • Gilda Rodriguez

    I am 69 years old and have been diagnosed 24 years ago and been on metformin for as many years with various combinations of drugs. My current combination is 1000 mg of metformin twice daily with 25 mcg Levemir insulin at bedtime. I have been plagued with stomach problems, diarrhea , gas etc. for the 24 years of metformin use and was unaware of the cause until 3 years ago. I live in Miami, Florida and would appreciate consideration for your study.

  • Keen Cummings

    I have been type 2 diabetic since 1990 so am not eligible for the test, but feel I should make those who also take Januvia aware that the new information says “may cause Pancreatitus”. I found this out the month after having come down with it. Januvia works great, but Pancreatitus is dangerous. I now have to take extra insulin but it is better than the desease. P.S., I also take Glyburide.

  • bob wyatt

    I am 71 years old I am taking metformin for 6 years with other drugs my blood sugar can be
    stable would like to be part of your study



  • Jason L. Hargrove,Sr.

    I had been taking Metformin for several years. Convinced my doctors that with weight loss and diet control that I did not need it any longer. Dosage was 1000mg twice a day. It pushed my glucose down to low. I could not take it at any dosage they prescribed.


  • emily hubbard

    I thought I wrote in to be considered for this study, but I don’t see my message anywhere. I was diagnosed as Type 2 diabetes about 6 years ago. I have been taking Metformin – 2 a day – for at least 6 years, along with my other medications for high blood pressure (diovan) and thyroid synthroid). I am currently being treated for statis dermatitis and have been checked out by different doctors for heart and other problems. Nothing has been found to cause the pooling in my legs which the doctors say has caused the statis dermatis. No one even looks at my legs or feet and they are horrible,painful, and it feels like I have red ants biting me 24 hours a day. I am concerned that there might be a link between all of this and the Type 2 diabetes. I would love to be in your study.

  • John H Schmelz

    I’m a type two diabetic who was on Metformin and at present not taking. When I was on it I had trouble keeping my numbers steady. Then a diet nurse helped me regulate my intake. I retired from teaching High School and I would like to get things steady. I’m looking to cut down on medications. I’m on a fixed income and still tutor students and teach children woodworking. I have learned that diet is the most important factor when regulating your blood sugar. Protien is my biggest problem and if I don’t add it to breakfast I fight my numbers all day. I was taking two 1000 mg a day along with others. I have only 1 3/4 of a kidney and have starting to gain weight again and want to trim back down. I would love to be part of your project.

  • Bob

    I started talking Metformin in the 90’s when it was only available in the brand name of Glucophage.

    I have never had any noticeable side effects from taking two 1000mg tablets/day, including the apparently common stomach problems. I also take Glimpiride twice a day. it is slowly getting harder to keep my glucose levels under control, but this combination has worked well for over 20 years.

    I would like to be part of the study but I guess they don’t want long-term users of metformin?