Metformin Provides Heart Benefits in Prediabetes

The oral diabetes drug metformin[1] may help reverse a potentially dangerous heart condition in people with prediabetes[2], according to new research in the European Heart Journal[3].


For the MET-REMODEL Trial, researchers randomly assigned 68 participants with coronary artery disease and insulin resistance[4] and/or prediabetes to take either 2,000 milligrams of metformin daily or placebo (inactive treatment). Compared to those taking placebo, patients taking metformin experienced reductions in left ventricular hypertrophy (LVH, a potentially life-threatening “enlargement and thickening of the walls of heart’s main pumping chamber”[5]), along with decreases in blood pressure and body weight.

According to researcher Nieca Goldberg, MD[6], LVH can result from untreated high blood pressure[7]. Only about 20% of people in the United States with high blood pressure have the condition well controlled, she added.

Additional research into the possible heart-protective benefits of metformin is needed from larger trials, the researchers note[8].

Want to learn more about metformin? Read “What to Know About Metformin,”[9] “Diabetes Medicine: Metformin,”[10] and “Metformin: The Unauthorized Biography.”[11]

  1. metformin:
  2. prediabetes:
  3. European Heart Journal:
  4. insulin resistance:
  5. heart’s main pumping chamber”:
  6. According to researcher Nieca Goldberg, MD:
  7. high blood pressure:
  8. the researchers note:
  9. “What to Know About Metformin,”:
  10. “Diabetes Medicine: Metformin,”:
  11. “Metformin: The Unauthorized Biography.”:

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Diane Fennell: Diane Fennell has been an editor at Diabetes Self-Management magazine since 2003. She is currently the Senior Digital Editor for Diabetes Self-Management E-News and (Diane Fennell is not a medical professional.)

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