Metformin Provides Heart Benefits in Prediabetes


The oral diabetes drug metformin[1] may help reverse a potentially dangerous heart condition in people with prediabetes[2], according to new research in the European Heart Journal[3].

Advertisement

For the MET-REMODEL Trial, researchers randomly assigned 68 participants with coronary artery disease and insulin resistance[4] and/or prediabetes to take either 2,000 milligrams of metformin daily or placebo (inactive treatment). Compared to those taking placebo, patients taking metformin experienced reductions in left ventricular hypertrophy (LVH, a potentially life-threatening “enlargement and thickening of the walls of heart’s main pumping chamber”[5]), along with decreases in blood pressure and body weight.

According to researcher Nieca Goldberg, MD[6], LVH can result from untreated high blood pressure[7]. Only about 20% of people in the United States with high blood pressure have the condition well controlled, she added.

Additional research into the possible heart-protective benefits of metformin is needed from larger trials, the researchers note[8].

Want to learn more about metformin? Read “What to Know About Metformin,”[9] “Diabetes Medicine: Metformin,”[10] and “Metformin: The Unauthorized Biography.”[11]

Endnotes:
  1. metformin: https://www.diabetesselfmanagement.com/managing-diabetes/treatment-approaches/metformin-2/
  2. prediabetes: https://www.diabetesselfmanagement.com/blog/prediabetes-what-to-know/
  3. European Heart Journal: https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehz203/5470456
  4. insulin resistance: https://www.diabetesselfmanagement.com/blog/insulin-resistance-need-know/
  5. heart’s main pumping chamber”: https://www.mayoclinic.org/diseases-conditions/left-ventricular-hypertrophy/symptoms-causes/syc-20374314
  6. According to researcher Nieca Goldberg, MD: https://www.healthline.com/health-news/how-diabetes-drug-metformin-can-reduce-heart-disease-risk#The-connection-with-blood-pressure
  7. high blood pressure: https://www.diabetesselfmanagement.com/managing-diabetes/complications-prevention/the-pressure-is-on/
  8. the researchers note: https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehz203/5470456
  9. “What to Know About Metformin,”: https://www.diabetesselfmanagement.com/blog/what-to-know-about-metformin/
  10. “Diabetes Medicine: Metformin,”: https://www.diabetesselfmanagement.com/blog/diabetes-medicine-metformin/
  11. “Metformin: The Unauthorized Biography.”: https://www.diabetesselfmanagement.com/managing-diabetes/treatment-approaches/metformin-2/

Source URL: https://www.diabetesselfmanagement.com/blog/metformin-provides-heart-benefits-in-prediabetes/


Diane Fennell: Diane Fennell has been an editor at Diabetes Self-Management magazine since 2003. She is currently the Senior Digital Editor for Diabetes Self-Management E-News and DiabetesSelfManagement.com. (Diane Fennell is not a medical professional.)

Disclaimer of Medical Advice: You understand that the blog posts and comments to such blog posts (whether posted by us, our agents or bloggers, or by users) do not constitute medical advice or recommendation of any kind, and you should not rely on any information contained in such posts or comments to replace consultations with your qualified health care professionals to meet your individual needs. The opinions and other information contained in the blog posts and comments do not reflect the opinions or positions of the Site Proprietor.