Metformin May Prevent Weight Regain


The oral diabetes drug metformin[1] may prevent weight regain in people who have shed pounds, according to a new study follow-up published in the Annals of Internal Medicine[2].

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Of participants who lost at least 5% of their body weight at 1 year in the landmark Diabetes Prevention Program[3] trial, those who took metformin maintained the greatest weight loss compared to those who changed their lifestyle or took a placebo (inactive treatment).

“Those who lost weight initially after 1 year had remarkable maintenance of the weight loss with metformin, something we had never known before,” said study author Kishore M. Gadde, MD, in an interview with Medscape Medical News[4].

Further studies are need to confirm the findings, Gadde noted, and doctors should decide on a case-by-case basis if the medicine is appropriate to help with weight maintenance, Leslie I. Katzel, MD, PhD, and John D. Sorkin, MD, PhD, stated in an accompanying editorial[5].

Want to learn more about metformin? Read “What to Know About Metformin,”[6] “Diabetes Medicine: Metformin,”[7] and “Metformin: The Unauthorized Biography.”[8]

Endnotes:
  1. metformin: https://www.diabetesselfmanagement.com/managing-diabetes/treatment-approaches/metformin-2/
  2. Annals of Internal Medicine: https://annals.org/aim/article-abstract/2731601/long-term-weight-loss-metformin-lifestyle-intervention-diabetes-prevention-program?utm_source=STAT+Newsletters&utm_campaign=710ae85400-MR_COPY_01&utm_medium=email&utm_term=0_8cab1d7961-710ae85400-149752709
  3. Diabetes Prevention Program: https://www.diabetesselfmanagement.com/diabetes-resources/definitions/diabetes-prevention-program/
  4. an interview with Medscape Medical News: https://www.medscape.com/viewarticle/912074
  5. an accompanying editorial: https://annals.org/aim/article-abstract/2731603/advising-patients-how-achieve-long-term-weight-loss
  6. “What to Know About Metformin,”: https://www.diabetesselfmanagement.com/blog/what-to-know-about-metformin/
  7. “Diabetes Medicine: Metformin,”: https://www.diabetesselfmanagement.com/blog/diabetes-medicine-metformin/
  8. “Metformin: The Unauthorized Biography.”: https://www.diabetesselfmanagement.com/managing-diabetes/treatment-approaches/metformin-2/

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