Metformin May Prevent Weight Regain

The oral diabetes drug metformin may prevent weight regain in people who have shed pounds, according to a new study follow-up published in the Annals of Internal Medicine.


Of participants who lost at least 5% of their body weight at 1 year in the landmark Diabetes Prevention Program trial, those who took metformin maintained the greatest weight loss compared to those who changed their lifestyle or took a placebo (inactive treatment).

“Those who lost weight initially after 1 year had remarkable maintenance of the weight loss with metformin, something we had never known before,” said study author Kishore M. Gadde, MD, in an interview with Medscape Medical News.

Further studies are need to confirm the findings, Gadde noted, and doctors should decide on a case-by-case basis if the medicine is appropriate to help with weight maintenance, Leslie I. Katzel, MD, PhD, and John D. Sorkin, MD, PhD, stated in an accompanying editorial.

Want to learn more about metformin? Read “What to Know About Metformin,” “Diabetes Medicine: Metformin,” and “Metformin: The Unauthorized Biography.”

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