The oral diabetes drug metformin may improve insulin sensitivity in overweight and obese adolescents with Type 1 diabetes, according to a small new study published in The Journal of Clinical Endocrinology & Metabolism.
The researchers randomly assigned 37 youth (ages 12–19) with Type 1 diabetes and overweight or obesity to receive three months of daily metformin or placebo (inactive treatment). Compared with placebo, metformin resulted in “significantly greater improvements” in insulin sensitivity.
“[W]e demonstrated that the addition of metformin to insulin therapy in overweight or obese youth with Type 1 diabetes improves whole-body and specifically peripheral muscle [insulin deficiency and resistance] over a 13-week period,” noted the researchers. “However, alternative approaches are likely needed to target the hepatic [insulin deficiency and resistance] of overweight/obese youth with Type 1 diabetes.”
Want to learn more about metformin? Read “What to Know About Metformin,” “Diabetes Medicine: Metformin,” and “Metformin: The Unauthorized Biography.”
Source URL: https://www.diabetesselfmanagement.com/blog/metformin-improves-insulin-sensitivity-in-youth-with-type-1-diabetes/
Diane Fennell: Diane Fennell has been an editor at Diabetes Self-Management magazine since 2003. She is currently the Editorial Director. (Diane Fennell is not a medical professional.)
Disclaimer of Medical Advice: You understand that the blog posts and comments to such blog posts (whether posted by us, our agents or bloggers, or by users) do not constitute medical advice or recommendation of any kind, and you should not rely on any information contained in such posts or comments to replace consultations with your qualified health care professionals to meet your individual needs. The opinions and other information contained in the blog posts and comments do not reflect the opinions or positions of the Site Proprietor.
Copyright ©2020 Diabetes Self-Management unless otherwise noted.