Metformin Improves Insulin Sensitivity in Youth With Type 1 Diabetes


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The oral diabetes drug metformin[1] may improve insulin sensitivity in overweight and obese adolescents with Type 1 diabetes[2], according to a small new study published in The Journal of Clinical Endocrinology & Metabolism[3].

The researchers randomly assigned 37 youth (ages 12–19) with Type 1 diabetes and overweight or obesity to receive three months of daily metformin or placebo (inactive treatment). Compared with placebo, metformin resulted in “significantly greater improvements” in insulin sensitivity.

“[W]e demonstrated that the addition of metformin to insulin therapy in overweight or obese youth with Type 1 diabetes improves whole-body and specifically peripheral muscle [insulin deficiency and resistance] over a 13-week period,” noted the researchers[4]. “However, alternative approaches are likely needed to target the hepatic [insulin deficiency and resistance] of overweight/obese youth with Type 1 diabetes.”

Want to learn more about metformin? Read “What to Know About Metformin,”[5] “Diabetes Medicine: Metformin,”[6] and “Metformin: The Unauthorized Biography.”[7]

Endnotes:
  1. metformin: https://www.diabetesselfmanagement.com/diabetes-resources/definitions/metformin/
  2. Type 1 diabetes: https://www.diabetesselfmanagement.com/diabetes-resources/definitions/type-1-diabetes/
  3. The Journal of Clinical Endocrinology & Metabolism: https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/jc.2019-00129/5423566?redirectedFrom=fulltext
  4. noted the researchers: https://www.endocrinologyadvisor.com/home/topics/diabetes/type-1-diabetes/metformin-improves-peripheral-insulin-sensitivity-in-young-patients-with-type-1-diabetes/
  5. “What to Know About Metformin,”: https://www.diabetesselfmanagement.com/blog/what-to-know-about-metformin/
  6. “Diabetes Medicine: Metformin,”: https://www.diabetesselfmanagement.com/blog/diabetes-medicine-metformin/
  7. “Metformin: The Unauthorized Biography.”: https://www.diabetesselfmanagement.com/managing-diabetes/treatment-approaches/metformin-2/

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Diane Fennell: Diane Fennell has been an editor at Diabetes Self-Management magazine since 2003. She is currently the Editorial Director. (Diane Fennell is not a medical professional.)

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