Trulicity Plus SGLT2 Drug Can Help Lower A1C


You’re working hard, watching your diet, exercising, and taking your medicine like clockwork, but still you dread receiving your A1C[1] results. For some people with Type 2 diabetes[2], however, the results of that test (which show average blood sugar control over the previous 2–3 months) may soon be looking up — or more accurately, down — thanks to a recent clinical study.

Advertisement

Findings of the phase IIIb AWARD-10 study published Feb. 23 in The Lancet Diabetes and Endocrinology[3] offer evidence that a new combination of therapies for Type 2 can lower glucose levels. The key is that each element of the combination combats the disease through different mechanisms.

The study followed 424 patients in eight countries over a period of 24 weeks, garnering positive results. The data showed that when a sodium-glucose co-transporter-2 (SGLT2) inhibitor[4], which blocks the protein that helps the kidneys reabsorb glucose, isn’t enough, the addition of dulaglutide (brand name Trulicity) can help. Dulaglutide is a weekly injectable glucagon-like peptide-1 (GLP-1) receptor agonist[5] that performs several tasks, all designed to keep blood sugar in check: limiting how much sugar is released into your bloodstream from your liver, slowing how quickly food leaves your stomach, and helping your pancreas release insulin in response to high blood sugar after you eat.

The combined therapy proved effective and safe for adults at two different dosages, and was studied both with and without metformin[6], another drug commonly used by people with Type 2 diabetes; it prevents the liver from releasing excess glucose and makes muscle and fat cells more sensitive to available insulin.

“I’ve seen in my practice that even with effective oral medicines like SGLT-2 inhibitors and metformin, many adults with Type 2 diabetes may still need additional therapy to maintain their blood sugar levels,” said Bernhard Ludvik, MD, an associate professor of medicine at Rudolfstiftung Hospital Vienna and AWARD-10 lead author. “The AWARD-10 results suggest that the combination of once-weekly Trulicity and an SGLT-2 inhibitor shows significant promise in helping more people with Type 2 diabetes reach their treatment goals.”

Of course, it’s not a magic cure, and it’s not recommended as a first line of treatment. People with Type 2 diabetes still need to maintain their diet and exercise routines. But in those who need it, the drugs were well-tolerated, with the biggest concerns being nausea, vomiting, and diarrhea.

“Managing Type 2 diabetes with diet, exercise, and oral medications may require the addition of injectable therapy for some people, given the progressive nature of the disease,” said Brad Woodward, MD, a senior medical director at Lilly Diabetes. “AWARD-10 showed that Trulicity, when used in combination with an SGLT-2 inhibitor and metformin, may be effective and well tolerated in people with type 2 diabetes.”

Want to learn more about SGLT2 inhibitors, GLP-1 receptor agonists, and metformin? Read “Diabetes Medicine: SGLT2 Inhibitors,”[7] “Diabetes Medicine: Non-insulin Injectable Diabetes Medications,”[8] and “Diabetes Medicine: Metformin.”[9]

Endnotes:
  1. A1C: https://www.diabetesselfmanagement.com/managing-diabetes/blood-glucose-management/h-b-a-1-c/
  2. Type 2 diabetes: https://www.diabetesselfmanagement.com/diabetes-resources/definitions/type-2-diabetes/
  3. The Lancet Diabetes and Endocrinology: http://www.thelancet.com/journals/landia/article/PIIS2213-8587(18)30023-8/supplemental
  4. sodium-glucose co-transporter-2 (SGLT2) inhibitor: https://www.diabetesselfmanagement.com/blog/diabetes-medicine-sglt2-inhibitors/
  5. glucagon-like peptide-1 (GLP-1) receptor agonist: https://www.diabetesselfmanagement.com/blog/non-insulin-injectable-diabetes-medications/
  6. metformin: https://www.diabetesselfmanagement.com/blog/diabetes-medicine-metformin/
  7. “Diabetes Medicine: SGLT2 Inhibitors,”: https://www.diabetesselfmanagement.com/blog/diabetes-medicine-sglt2-inhibitors/
  8. “Diabetes Medicine: Non-insulin Injectable Diabetes Medications,”: https://www.diabetesselfmanagement.com/blog/non-insulin-injectable-diabetes-medications/
  9. “Diabetes Medicine: Metformin.”: https://www.diabetesselfmanagement.com/blog/diabetes-medicine-metformin/

Source URL: https://www.diabetesselfmanagement.com/blog/adding-trulicity-to-sglt2-inhibitor-can-help-lower-a1c-clinical-study-shows/


Debra Filcman: Debra Filcman is a freelance journalist and copywriter who writes about a wide range of topics, but specializes in health/wellness and arts/culture. A native of New York City, she now calls Chicago home.

Disclaimer of Medical Advice: You understand that the blog posts and comments to such blog posts (whether posted by us, our agents or bloggers, or by users) do not constitute medical advice or recommendation of any kind, and you should not rely on any information contained in such posts or comments to replace consultations with your qualified health care professionals to meet your individual needs. The opinions and other information contained in the blog posts and comments do not reflect the opinions or positions of the Site Proprietor.