New Metformin Combination Medicine Approved for Type 2 Diabetes

On October 30, the US Food and Drug Administration (FDA) approved the combination oral diabetes drug Xigduo XR for use, along with a healthful diet and exercise, in adults with Type 2 diabetes. The medicine, a development of AstraZeneca, combines dapagliflozin (brand name Farxiga), an SGLT2 inhibitor, and extended-release metformin (Glucophage XR and others).

In the process of filtering the blood, the kidneys typically reabsorb all the filtered glucose and return it to the bloodstream. One of the main proteins responsible for this reabsorption is SGLT2. By inhibiting the action of SGLT2, Farxiga blocks the reabsorption of glucose by the kidneys, promoting a loss of glucose in the urine and lowering blood glucose levels. Metformin works by decreasing the amount of glucose made by the liver and by improving insulin sensitivity in the liver, muscle, and fat cells.


Xigduo XR, the first once-daily combination tablet of an SGLT2 inhibitor and extended-release metformin approved in the United States, will be offered in doses of 5 milligrams of dapagliflozin/500 milligrams of metformin, 5 milligrams of dapagliflozin/1,000 milligrams of metformin, 10 milligrams of dapagliflozin/500 milligrams of metformin, and 10 milligrams of dapagliflozin/1,000 milligrams of metformin to be taken once a day in the morning with food.

This medicine should not be used in people with Type 1 diabetes, diabetic ketoacidosis (a potentially life-threatening condition marked by a chemical imbalance in the body), or moderate to severe kidney impairment. Because of the inclusion of metformin, Xigduo XR carries the risk of a rare but serious metabolic complication known as lactic acidosis.

The most commonly reported side effects of Farxiga plus metformin compared to placebo (inactive treatment) plus metformin include female genital fungal infections, inflammation of the nasal passages and upper pharynx, urinary tract infections, diarrhea, and headache. The most commonly reported side effects of extended-release metformin compared to placebo are diarrhea and nausea/vomiting.

For more information about Xigduo XR, see the press release on the AstraZeneca website.

  • Cindy Baker

    I have such a hard time controlling my b.s. and would be willing to try this too. I s ready take metformin 750 er twice a day with 90-100u of Lantus.

  • Patricia FaKouri

    Sounds like the combination is very strong….how safe is this combo on the kidneys….and how long has this combo been tested…..

    I am interested in changing my meds….

  • Dee J

    My niece works for a company that sells another drug just like the new one here and she has told me about the doctors complaining about the yeast infections galore. One lady from church was put on this new one and her expression cannot be politely repeated here. to say the least; she threw it away and told the doctor to wake up and smell the roses. It is strong. Both of the drugs released recently do the same thing taking the sugar out thru the intestines. I haven’t found one person who liked it and stayed on it.
    metformin is another story and most of us can stand it. this one can inflame the nasal passages too. Asthma and allergies, bronchitis, etc. Not too good sounding to me.

  • Don King

    I would try this. I already take Metformin er 1000 mg daily but it is not working as good as it once did.

    I am on medicare and it would have to be in the formulary in order for me to be able to afford it.

  • gerald henderson

    I have type two really bad.metformin twice a dayand insulan at night still doesn’t keep it in check.would love to try something better if it works.

  • lou

    I tried the new extended release and was so glad my DR. prescribed it..-then came the disappointment.
    This pill is so large you can’t swallow it without choking and it can’t be split because then its not extended release.
    Wish they made it in an easier to swallow form.

  • Jerry smith

    I would like more info on this drug. I am very interested in trying it0

  • Linda Sparrow

    I am interested in trying this drug. I am a typw II
    diabetic. I am now taking 1000mg metforimin twice a day and 5mg glipizide three times a day.

  • Helen Bouhl

    Would this help me if I am insulin resistant?

  • Susan

    When my Type 2 was out of control and 1000 mg Metformin twice a day and 65 units of Lantus Insulin was still leaving my A1C number too high, my doctor left me on the same dosage of Metformin, lowered the Lantus to 46, and added a fast acting sliding scale insulin called Novolog, my numbers came down to where they should be. But everybody is different and I have had diabetes for 26 years.
    Kidney Disease is also very stable.

  • Angela Middleton

    I am very interested in trying this medication please keep me informed.

  • karen

    I take 2000 mg metformin daily along with 95 units of insulin (lantus) at nite. I also have high cholesterol and blood pressure. Ive recently had CABG surgery and 3 procedures on my bronchial tubes for my asthma. There are other things as well. Would I be a candidate for this new drug?

  • david prevost

    dr glenn moran has prescribed metformin. no real effect is noticed besides gas. would like something better.

  • diana

    This would be so much easier than remembering to take 4 metformins a day…how do I go about asking my Dr. About this and where to locate who has the medication available?

  • Linda Hempfling

    I have been on Farxiga for 2 months. I have had 2 side effects. The first is a minor thing-sometimes a runny nose, etc. However the second side effect is major to me. I already have overactive bladder and thus major leaking problems. The Farxiga has made that a MAJOR problem–EVERYTIME I stand up, sit down or otherwise “exercise” I have a major leaking of urine–using regular size bath towels on the floor means that after I stand up, I can expect the towel to be filled enough that I can wring liquid out of the towel. The is in addition to the “maximum” pads that I wear, which are completely filled EACH time I stand up. I am also on Metformin, but I would be afraid that the combination would also give me the same side effect of EXCESSIVE urination that the individual drug of farxiga does.
    Therefore, I would be reluctant to take the combination drug, even though I am happy with my metformin.

  • Dawn

    I’m currently taking Invokanna, Metformin, Lantis once a day and Humalog 2x a day. My BS is low now, but I have a mean yeast infection. My next visit to my endocrinologist is next week to decrease the dosage of the Invokanna. The side effects of all these drugs suck.

  • Jossie Mpran

    I Will be more than willing to try this combo. Metformin does not control my diabetes very well.

  • Jerry

    I would be interested as long as it does not give you diaherra like regular metformin does

  • Dan Quan

    Looking forward to trying new formulation.

  • Kathy Cotreau

    I have type 2 diabetes and am taking 500mg of Metformin once a day. However I also have valvular heart disease, had 2 valves replaced with mechanical valves, thus I am also on Coumadin. Does this medication have any effect on Coumadin levels?

  • Lisa Mathes

    I have never been able to control my sugars. I take 5 shots plus pills every day. I would love to try something new.

  • Albert Lyles

    I would try to see if it would help. I take 500 mg daily metformin.

  • Charlotte

    I have just restarted taking care of my Diabetes. I am Type 2. I would be interested in knowing more about this medication and would consider trying it.

  • Jimmy C. Perales

    I would like to try it. I take metforman for 5 yrs already

  • William

    I currently take Metformin 2 times day . It has helped me but I tend to not be able to lose weight with it. I am wanting another option, maybe this new combo metformin just approved is what I am looking for. Very excited!

  • Tom Bogan

    I take 2000mg Metformin, 2mg glyburide daily and bydureon weekly. I would like to see how this drug compares to my regimen.

  • pedro r.gonzales

    i would like to improve on my B.S count I take 2 =1000 mg and Glipizide a day now.

  • pedro r.gonzales

    i take 2 metformin + glipzide some new would help

  • pedro r.gonzales

    i want try something new

  • pedro r.gonzales


  • pedro r.gonzales

    I would like more information to try a new medication

  • pedro r.gonzales sr

    Never mind i tried several times no sucess

  • Patricia Cooper

    I have been taking Metformin for years I take 4 a day and now using an injection 1 time a week. My B S is hard to controll. I am going to ask my Doctor about it.

  • Dustin J Eitniear

    I take Metformin 500 mg three times a day with 53 units of Lantus Solostar. I would be willing to try this drug to replace the three a day doses.

  • Sharon

    I am currently taking 10 mg glipizide twice a day, Janumet 50/1000 twice a day and 35 units of Lantus Solostar at night. I still have A1C levels at about 11 … I need help.

  • Dr. Gail Devoid

    I am interested.

  • tony rossow


  • Kathy

    I already take Metformin twice a day, when I remember to take it. A time release form would be a huge help.

  • Joanne

    I would be willing to try it. I have had swings in blood sugar and have been taking insulin for about a month now. 10 mg Lantus and my morning readings are still very high.

  • Emma

    I take 1000 MG of Metformin twice a day, 10 MG of Glipizide and 30 MG of Pioglitazone once a day. Would this new medicine for diabetes be of benefit to me?

  • Karen Renner

    I would be interested in trying this product.

  • Eddie

    I would really like to try this new medication


    I would be interested in this. My doctor just increased my meds from 1000 to 1500 mg.

  • Daniel Frank

    I take metformin and shots, still have trouble controlling my blood sugar. I would love to try this.

  • terri

    Taking gliprimide and metaphormin both 2 x day.
    It would be nice to have I medicine to take care of controlling the diabetes.

  • Ferne

    I have heard bad things about this drug and when it is offered free for a year I question it. I would also question the cost for us who have insurance. New drugs are usually more expensive and insurance won’t accept them. Does it have the same bad side affects as metformin?

  • chris

    I would be willing to try,but my MD said it would be too expensive

    • Michelle Anderson Kendall

      Chris I get the farxiga/ metformin free for a yr so could you

      • Melanie

        Hi Michelle. I was reading the posts today about metformin and farxiga and would be interested in how you receive the meds free for a year. Would you mind sending me a reply.

  • Kenneth

    I take metphorman 3 times aday and i would be willing to try this to help control my b.s. it would be nice to see my b.s stay down, aweful nice

  • teresa ruhl

    I would really be interested in trying this, my bs spikes all the time and my feet hurt really bad. I take 3 metformin pills a gay and 3 insulin shots a day, I would love to try this to cut back on all I am taking. I have had 1/2kidney removed and my liver is enlarged.

  • Elf

    I would love to be able to take Metformin but each time I try it I have severe diahhrea. Would this be any better or much the same?

  • Arlene Jones

    I take 2000mg metformin daily and still have
    problems. Would be interested in trying a new med to help get the diabeties under control or preferably gone.

  • pat

    am taking kombiglyze xr 1000 gm twice a day. have the option of taking glyburide 4 gm for heavy carbs if I choose to have them. I have great results with it. my A1C was 5.7. I am not changing anything. I am happy with the results I have. Any drug that can give me bladder infections and the like I want to avoid. I am afraid these new meds have too many side affect for my tastes. Janumet can cause problems with the pancreas , advandia caused heart problems and killed folk. I saw on tv that a new drug caused kidney problems. Who needs that along with diabetes??? Not me and i am not interested.

  • Sandy Greene

    I take 2 500 MG of metformin ER twice a day. I take twice day 75/25 Humalog – 20 units at night and 12 units in the morning. My readings are 80 to 200 in the morning now where they use to be 140 to 300 with some wild swings up to 500. I would love to discuss with my doctor if this is something that he feels would be good for me to try.

  • Junne Jewell

    Am trying to get my numbers down. Junne

  • Charlene

    I would be willing to try this new medication provided my DR thinks it would be a good fit for me. I have been on Metformin since 2004.

  • Jean McNeill

    I am currently taking “Janumet” – would like to know if this is basically the same type drug??


  • Margaret Brown

    When I saw my endocronoligist in July, 2014, my blood sugars were out of control in the 200’s & 300’s. My Aic was 12, and I had protein in my urine.
    As of that visit, my Dr. added Farxiga in addition to what I was already taking,Janumet/Metformin 50/1000 at breakfast & supper, along with 1/2 tab 2mg of glimeperide,at supper.
    I have an appt. with my Dr. on Wed, Nov 12th. I am anxious to see where my Aic is at. My blood sugars have been stable in my range of 70-140, along with diet and exercise. I have also lost around 18 lbs. in which the Farxiga has played a part.
    I have been on Medicare since Sep 1 and the Farxiga is not in the AARP RX program through United Healthcare. The Janumet/Metformin is also not in the formulary, but is affordable with this plan. I will ask my Dr. about this new drug, which I think is a generic for Farxiga and check with my Rx Plan to find out the cost.
    If it is in the formulary and would be a generic, the cost in minimal.

  • Laura Ann Tribble

    My husband and I would both be interested in trying the new medication. He was diagnosed as Type2 several years ago with daily readings from upper 200s to upper 300s.
    I was recently diagnosed as Type 2 and placed on glyburide with Horrible side effects!

  • Michelle Anderson Kendall

    I have been taking farxiga/ metformin once a day not only are my numbers down I’m loosing weight. So far no side effects and it’s free for a yr :-)

    • Renee James

      How much weight have you lost and would you mind sharing how the meds were free? I currently take metformin and thinking of discussing the farxiga with my doctor.

      • Marella Miles

        I take my prescriptions to Publix and get them free there.

  • Renee James

    How can someone go about getting both of the drugs for free? Can you advise and send info?

  • sue coggins

    I have been taking Farxiga 10 mg since April this year. At check-up with GP i had lost 8 lbs. This month i developed killer fungus infection. Terrible rawness,awful pain. I stopped the med.. Yesterday and got neomycin a.antibiotic cream with pain control. I am out of town now, actually different country, so
    Must manage this myself. Horrors-the pain. I never wamt to suffer this again.