Diabetes Self-Management Articles

These articles cover a wide range of subjects, from the most basic aspects of diabetes care to the nitty-gritty specifics.

Links not loading properly?

Some of our pages use Portable Document Format (PDF) files, which require Adobe Acrobat Reader. To download Acrobat Reader for free, visit www.adobe.com.

Sign up for our weekly e-mail newsletter and receive a FREE GIFT! Enter your e-mail below.

Learn more

Learn more about diabetes

Links to help you learn more about diabetes.

Ask a diabetes expert
Other diabetes resources
Browse article topics

 

Beta-Cell Regeneration

Another potential treatment is the combination of two growth factors called gastrin and epidermal growth factor (EGF), which has been shown to promote beta-cell regeneration in rats. Researchers at Waratah Pharmaceuticals in Woburn, Massachusetts, developed this combination for therapy, calling it Islet Neogenesis Therapy (INT). In 2004, an extended phase I clinical trial of INT in people with Type 1 diabetes, designed to test the safety of the therapy, showed no serious or unexpected side effects.

In a study reported in the Journal of Clinical Endocrinology and Metabolism in 2005, researchers from Waratah and the University of Alberta in Edmonton, Alberta, Canada, cultured human islets for four weeks in medium containing neither agent, gastrin or EGF alone, or a combination of EGF and gastrin. The islets were then cultured for another four weeks in a control medium. At the end of the second four-week period, the group receiving the gastrin-EGF combination had three times as many insulin-producing beta cells as they started with.

Next, the researchers implanted human islets into NOD-SCID mice — mice with a deficient immune system — so as to sidestep transplant rejection and autoimmunity. They then injected some of the mice with the EGF-gastrin combination. In the mice treated with EGF-gastrin, there was an increase in beta cell numbers and insulin levels within the islets. When they injected glucose into the mice, there was a brisk secretion of insulin from the human islet grafts, demonstrating that the beta cells were functional. Research into the promise of beta-cell regeneration continues.

Page    1    2    Show All    

 

 

More articles on Diabetes Definitions

 

 


Statements and opinions expressed on this Web site are those of the authors and not necessarily those of the publishers or advertisers. The information provided on this Web site should not be construed as medical instruction. Consult appropriate health-care professionals before taking action based on this information.

 

 

Can Beta Cells Be Healed?
Can Type 2 or Type 1 diabetes be not only reversed, but cured? Can beta cells start producing... Blog

Toxic Chemicals and Type 1
Last week I wrote about research showing that environmental chemicals are major causes of Type... Blog

Breakthrough or Tease?
Dr. Denise Faustman, a researcher at Massachusetts General Hospital in Boston who runs a lab... Blog

I've been experiencing high blood glucose a lot lately. Is there anything I can do? Get tip