Diabetes Self-Management Blog

The injected diabetes drug pramlintide (brand name Symlin) is now available in pen form. Drug manufacturer Amylin Pharmaceuticals, Inc., announced this week that two new prefilled, pen-injector devices—the SymlinPen 120 and the SymlinPen 60—are now on the market to make the process of injecting mealtime doses of pramlintide simpler and more convenient. Until this week, pramlintide was only available in vials.

The new pens will allow users to inject different fixed doses of pramlintide. The SymlinPen 120 can deliver 60 or 120 micrograms of pramlintide per dose, while the SymlinPen 60 can deliver 15, 30, 45, or 60 micrograms of pramlintide per dose. Both pens can be stored at room temperature (though not to exceed 86° F) once they are in use.

Pramlintide was approved by the U.S. Food and Drug Administration (FDA) in March 2005 for use in people with Type 1 diabetes and people with Type 2 diabetes who take mealtime insulin. Pramlintide is a synthetic analog of the human hormone amylin, which is usually made by the beta cells of the pancreas (the same cells that produce insulin). People with diabetes whose pancreases don’t produce enough (or any) insulin also don’t produce enough amylin at mealtimes.

Injecting pramlintide at mealtimes along with insulin can help people with diabetes control their after-meal blood glucose levels. Several mechanisms contribute to this effect, including slowed stomach emptying. This action can help people feel more full and eat less food; in fact, pramlintide has been shown to help people who are overweight or obese lose weight (see the blog entry “Symlin May Help Obese People Lose Weight.”) The most common side effect of pramlintide treatment is nausea.

In a prepared statement, President and CEO of Amylin Pharmaceuticals Daniel M. Bradbury said that the new pramlintide pens “will make it easier for…patients using multiple daily injections to start and stay with Symlin.” Pramlintide user Jan Chait, who has been waiting for a pen to become available, has blogged about the positives and negatives of her experiences using the drug in “Symlin: Sometimes the Positives Outweigh the Negatives.” You can also read more about pramlintide therapy in the article “Exenatide and Pramlintide: New Meds on the Block”.


  1. I take Lantus and have reg insulin at mealtime. by scale Can Symlin be used this way? I eat out often or am gone from my house so a pen would be great. Can someone let me know via e-mail..

    Posted by rethamac |
  2. where can i bay symlin-pen

    Posted by kiki1905 |
  3. Hi kiki,

    You can call your local pharmacies to see if they stock the SymlinPen, but keep in mind that it is available by prescription only, so you will need to see your doctor if you’re interested in trying it.

    Posted by Tara Dairman, Web Editor |
  4. Is there any place out there that will help pay for Symlin. I am a Type 2 Diabetic and have had it for almost 27 years. My Endocrinologist and Dietician just recently started me on Symlin,but my insurance company will not pay for it. I have Medicare Part D and Medicaid. Any help would be greatly appreciated.

    Posted by coolpanda58 |
  5. I just started Symlin and my insurance won’t pay for it. I’m type 2 diabetic and overweight. I pray the symlin will help in weight loss and control my sugar. Is there coupons for this med. Thanks

    Posted by Dearly |
  6. I am on the Symlin pen and i can not afford the copay for it and my ins ends march 1st 2011. I’m type 2 diabetic and overweight and i have severe cardiovasuclar disease and i have had fempop surgery on both legs i have had a couple heart attacks and i have had a double bypass open heart surgery. I pray the symlin will help in weight loss and control my bloodsugar level. Is there coupons for this med or an assistance program. Thank you

    Posted by peggy |
  7. I have type II diabetis and have been using the symlin pen for a few months now. I am in the low income bracket and find it hard to be able to pay for the pens…and am trying to decide how long I will be able to continue this med. I even have extra help for my meds but still find it to costly for me. Is there a Pharmaceutical Company that can assist me with the cost of my Symlin Pen? I’ve been overweight most of my life which doesn’t help with my diabitis…however, it does seem to help the weight problem while i’ve been on the symlin pen. Please reply.

    Posted by Barbara Singer-Santoro |

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