Diabetes Self-Management Blog

Resveratrol, a plant compound known to have various antioxidant and anti-inflammatory properties in yeast, worms, fruit flies, fish, and mice, also appears to combat inflammation in humans, according to a recent study by endocrinologists at the University of Buffalo. Chronic inflammation is thought to play a role in many diseases, including Type 2 diabetes, heart disease, and stroke.

Resveratrol is produced by a number of plants, including peanuts, blueberries, bilberries, cranberries, and red grapes (it’s also found in red wine), in response to attacks by pathogens such as bacteria. It is also found in Japanese knotweed, a plant considered invasive in parts of the United States. However, makers of nutritional supplements currently use Japanese knotweed as a source of resveratrol. Previous research has indicated that resveratrol can prolong life and reduce the rate of aging in organisms such as roundworms and yeast, and animals studies have indicated that supplementation may also help to increase insulin sensitivity.

To determine whether resveratrol could have any of these effects in humans, researchers randomly assigned 20 volunteers to receive either a nutritional supplement containing 40 milligrams of resveratrol or an identical placebo pill without resveratrol. Study participants took one pill a day for six weeks; fasting blood samples were drawn at the beginning of the study and at weeks one, three, and six.

The tests showed that those in the resveratrol group experienced suppression of free radicals, unstable molecules that contribute to oxidative stress and inflammation in the body and that can ultimately cause blood vessel damage. People in this group also showed suppression of a protein known as tumor necrosis factor (TNF) and other substances known to increase inflammation and interfere with the action of insulin. Those in the placebo group did not have a change in their blood levels of these substances.

While the results of this study are promising, senior author Paresh Dandona, MD, PhD, noted that another substance in the plant extract used in the study might be responsible for the beneficial effects. He explained that “The product we used has only 20 percent resveratrol, so it is possible that something else in the preparation is responsible for the positive effects. These agents could be even more potent than resveratrol. Purer preparations are now available and we intend to test those.”

For more information, read “Plant Compound Resveratrol Shown to Suppress Inflammation, Free Radicals in Humans” or see the study’s abstract in The Journal of Clinical Endocrinology & Metabolism.


  1. I took resvertrol for six months and eventually developed breathing problems.

    Posted by Harry......................... |
  2. Research shows that Red Muscidines have 10 to 20 times the level of resveratrol as Red Grapes. Has this source been investigated?

    Posted by Benny |
  3. Kind of pathetic research and summary.

    “Oh yeah, looks great, but actually, doesn’t prove anything, because there were other items in the supplement.”

    Hmmm. Why not just let us know which supplement you used, and we’ll take it, since whatever it was in the supplement, IT HELPED.

    But YEAH, if you want to study Resveratrol, you should give JUST THAT as the differentiator. Otherwise, it’s like saying… “I think chocolate ice cream cures cancer — here, try some Neapolitan ice cream. Oh, that helped, but maybe it was the vanilla or the strawberry, and not the chocolate.”

    Posted by Charlie Levenson |
  4. One does have to question these ’scientific studies’….nature provides perfect balances in ALL foods if grown & eaten without additives or manipulation. Knotweed like many others considered ‘pests’ are ’storehouses of wonder’-but lets get real here - FOLLOW A NATURAL DIET - whether you have diabetes or not…….if diabetes doesn;t get you….I’m sure science will find something else that will.

    Posted by Gypsy Wommyn |
  5. Resveratrol is an exciting “anti ageing” compound found in red wine, grape skin, Japanese Knotweed, peanuts and some berries.

    Posted by todors |
  6. Yup. Be like the French and drink a glass or two (wine glass size) of dark red wine every day.

    Posted by jim snell |

Post a Comment

Note: All comments are moderated and there may be a delay in the publication of your comment. Please be on-topic and appropriate. Do not disclose personal information. Be respectful of other posters. Only post information that is correct and true to your knowledge. When referencing information that is not based on personal experience, please provide links to your sources. All commenters are considered to be nonmedical professionals unless explicitly stated otherwise. Promotion of your own or someone else's business or competing site is not allowed: Sharing links to sites that are relevant to the topic at hand is permitted, but advertising is not. Once submitted, comments cannot be modified or deleted by their authors. Comments that don't follow the guidelines above may be deleted without warning. Such actions are at the sole discretion of DiabetesSelfManagement.com. Comments are moderated Monday through Friday by the editors of DiabetesSelfManagement.com. The moderators are employees of Madavor Media, LLC., and do not report any conflicts of interest. A privacy policy setting forth our policies regarding the collection, use, and disclosure of certain information relating to you and your use of this Web site can be found here. For more information, please read our Terms and Conditions.

Nutrition & Meal Planning
Hype or Healthy? Ezekiel Bread and Whey Protein (10/20/14)
Hype or Healthy? Chia Pudding and Bulletproof Coffee (10/14/14)
Low-Carb Diet Improves Quality of Life in Type 2 Diabetes (10/07/14)
Soup Really Is Good Food (10/06/14)

Diabetes Research
Can Grapefruit Juice Prevent Weight Gain, Increase Insulin Sensitivity? (10/16/14)
Low-Carb Diet Improves Quality of Life in Type 2 Diabetes (10/07/14)
Long Hours at Low-Income Jobs Linked to Increased Diabetes Risk (10/02/14)
Statins May Reduce Risk of Nerve Damage, Other Diabetes Complications (09/18/14)

Diabetes News
Can Grapefruit Juice Prevent Weight Gain, Increase Insulin Sensitivity? (10/16/14)
Low-Carb Diet Improves Quality of Life in Type 2 Diabetes (10/07/14)
Long Hours at Low-Income Jobs Linked to Increased Diabetes Risk (10/02/14)
New Weekly Type 2 Diabetes Drug Approved (09/26/14)

Diane Fennell
Take Part in the Big Blue Test! (10/15/14)
Can Grapefruit Juice Prevent Weight Gain, Increase Insulin Sensitivity? (10/16/14)
Low-Carb Diet Improves Quality of Life in Type 2 Diabetes (10/07/14)
Long Hours at Low-Income Jobs Linked to Increased Diabetes Risk (10/02/14)



Disclaimer of Medical Advice: You understand that the blog posts and comments to such blog posts (whether posted by us, our agents or bloggers, or by users) do not constitute medical advice or recommendation of any kind, and you should not rely on any information contained in such posts or comments to replace consultations with your qualified health care professionals to meet your individual needs. The opinions and other information contained in the blog posts and comments do not reflect the opinions or positions of the Site Proprietor.

Blood Glucose Self-Monitoring — Part 3: Smart Monitoring

10 Keys to Long-Term Weight Loss

Take Your Best Shot: Stay Up to Date on Vaccines

Complete table of contents
Subscription questions