Diabetes Self-Management Blog

People at high risk of having a heart attack or stroke can cut their risk by as much as 80% by using a combination of three common medicines — all of them available as generics — according to a recent study published in The American Journal of Managed Care. Heart disease death rates and the risk of stroke are roughly two to four times higher in adults with diabetes than in people without diabetes.

To evaluate the impact of a generic statin (cholesterol-lowering medicine), a generic blood pressure pill, and low-dose aspirin in high-risk individuals, researchers followed 68,560 people over the age of 55 who had diabetes or heart disease and who were not taking the combination of drugs used in the study — a 40-milligram dose of the cholesterol-lowering drug lovastatin and a 20-milligram dose of the blood-pressure-lowering medicine lisinopril. In addition to being prescribed these two drugs, people in the study were encouraged, but not required, to take a daily low-dose (83-milligram) aspirin.

The researchers used prescription records to determine which participants were actually taking the prescribed medicines and how often over the course of a two-year period. (Although aspirin use could not be monitored because it is an over-the-counter medicine, the investigators estimated that roughly 75% of the participants were taking aspirin.)

Results of the one-year follow-up period showed that people who took the two-drug combination as little as 22% of the time reduced their risk of a heart attack or stroke by more than 60%. And those who took the combination at least half the time reduced their risk by roughly 80%. The researchers estimated that 1,271 heart attacks and strokes were prevented in the first year after the treatment period. What’s more, the combination treatment caused no apparent side effects.

According to lead study author R. James Dudl, MD, “This is a proven program that can be applied in many settings to reduce heart attacks and strokes… What was fairly amazing to me was that we got such a good drop in heart attack and strokes despite the low adherence.”

Although lovastatin was the cholesterol-lowering medicine used in the study, the researchers now recommend simvastatin, which has been shown to be even more effective, as part of the three-drug regimen.

For more information, read “Cheap three-drug combination helps cut heart risks” or see the study in The American Journal of Managed Care.


  1. If you happen to be on Lipitor along with generic blood pressure lowering meds (2) and low dose aspirin, would that most likely be just as effective as the generic used in the study?


    Posted by oliver |
  2. What is needed is a cholesterol lowering drug that is not a statin. Welchol works for a while but induces constipation in the long term.

    Posted by Harry......................... |
  3. It is really good news that these generic drugs work so well when the name brands of the same drugs cost so very much more

    Posted by Joseph Kubica |
  4. I have been on this combination of med’s for more than fifteen years. I am now 66 years of age. My father and grandfather died of hypertension at age 57. I had a triple by-pass at 57. I have had type I diabetes for more than fifty years with no complications. All my doctors agree the by-pass was needed because of heredity rather a complication of diabetes since I am in total compliance.

    I take my medications on-time all-the-time. My HgAic is 6.1. I have low blood sugars and will soon be on a CGM to help with the hypoglycemic unawareness.

    Posted by Charles Ferguson |
  5. I take Felodopine, Zocor, 400 mg. Toprol XL, 320mg. of Diovan, Clonidine and Hydralazine. I feel that this has kept me free of a stroke and heart attack. I also take Coumadiin.

    Posted by Charlotte |
  6. what happens if you can’t take statins due to the adverse side effects of muscle pain, aching joints, no stamina, some memory loss, etc?? And why such a high dose especially if your “numbers” are really good, you are excerising and eating correctly???? Please help.

    Posted by Susan |
  7. I am currently on 1 20 mg. tablet of lipitor and 1 5/20 mg.cap. of lotrel and 1 50/12.5 mg. tab. of hyzaar. will these drugs give me the same benefits as what your reccomending.

    Posted by bal mione |

Post a Comment

Note: All comments are moderated and there may be a delay in the publication of your comment. Please be on-topic and appropriate. Do not disclose personal information. Be respectful of other posters. Only post information that is correct and true to your knowledge. When referencing information that is not based on personal experience, please provide links to your sources. All commenters are considered to be nonmedical professionals unless explicitly stated otherwise. Promotion of your own or someone else's business or competing site is not allowed: Sharing links to sites that are relevant to the topic at hand is permitted, but advertising is not. Once submitted, comments cannot be modified or deleted by their authors. Comments that don't follow the guidelines above may be deleted without warning. Such actions are at the sole discretion of DiabetesSelfManagement.com. Comments are moderated Monday through Friday by the editors of DiabetesSelfManagement.com. The moderators are employees of Madavor Media, LLC., and do not report any conflicts of interest. A privacy policy setting forth our policies regarding the collection, use, and disclosure of certain information relating to you and your use of this Web site can be found here. For more information, please read our Terms and Conditions.

Oral Medicines
Statins May Reduce Risk of Nerve Damage, Other Diabetes Complications (09/18/14)
New Metformin Combo Drug Approved for Type 2 Diabetes (08/13/14)
FDA Approves New Oral Drug for Type 2 Diabetes (08/07/14)
New SGLT Drugs Coming (07/23/14)

Heart Health
Self-Manage Your Blood Pressure (09/02/14)
Pistachios Offer Protection for People With Diabetes (08/29/14)
Which Butter (or Spread) Is Better? (07/28/14)
High-Salt Diet Doubles Heart Risk in Type 2 Diabetes (07/25/14)

Diabetic Complications
Statins May Reduce Risk of Nerve Damage, Other Diabetes Complications (09/18/14)
New Approach for Neuropathy Pain? (08/18/14)
Study Evaluating Treatment for Neuropathy Pain (07/08/14)
Good Control Now = Lifetime Benefit (06/25/14)

Diabetes Research
Can Grapefruit Juice Prevent Weight Gain, Increase Insulin Sensitivity? (10/16/14)
Low-Carb Diet Improves Quality of Life in Type 2 Diabetes (10/07/14)
Long Hours at Low-Income Jobs Linked to Increased Diabetes Risk (10/02/14)
Statins May Reduce Risk of Nerve Damage, Other Diabetes Complications (09/18/14)

Diane Fennell
Take Part in the Big Blue Test! (10/15/14)
Can Grapefruit Juice Prevent Weight Gain, Increase Insulin Sensitivity? (10/16/14)
Low-Carb Diet Improves Quality of Life in Type 2 Diabetes (10/07/14)
Long Hours at Low-Income Jobs Linked to Increased Diabetes Risk (10/02/14)



Disclaimer of Medical Advice: You understand that the blog posts and comments to such blog posts (whether posted by us, our agents or bloggers, or by users) do not constitute medical advice or recommendation of any kind, and you should not rely on any information contained in such posts or comments to replace consultations with your qualified health care professionals to meet your individual needs. The opinions and other information contained in the blog posts and comments do not reflect the opinions or positions of the Site Proprietor.

Blood Glucose Self-Monitoring — Part 3: Smart Monitoring

10 Keys to Long-Term Weight Loss

Take Your Best Shot: Stay Up to Date on Vaccines

Complete table of contents
Subscription questions